***MENINGITIS***

PATHOPHYSIOLOGY 

Microorganisms 

                /            \   

               /              \

      Direct to CSF                                                Via BLOOD

 _________________________________________

Subarachnoid space

 from Astrocytes+Microglia

Cytokine Release

Increase Blood-Brain Barrier         Increase number of WBC in CSF              Vasculitis of Cerebral vessels

Permeability
                             

Fluid leakage from vessels             Inflammation of Meninges                          Decrease cerebral blood flow

Vasogenic edema                           Interstitial Edema                                      Ischemia,cytotoxic edema

                                                        (increase ECE)
                                                 

Cerebral Edema

Decrease Cerebral Blood Flow, Ischemia,  Apoptesis (BRAIN DEATH)